Skip Navigation
Skip to contents

Res Vestib Sci : Research in Vestibular Science

OPEN ACCESS
SEARCH
Search

Articles

Page Path
HOME > Res Vestib Sci > Volume 19(4); 2020 > Article
Case Report
심한 두통을 동반한 항GQ1b 항체 증후군
최서영1, 김경해2, 김종국3,4, 김남준4, 김영희4, 최광동1orcid
Anti-GQ1b Antibody Syndrome Presenting with Severe Headache
Seo-Young Choi1, Kyeung-Hae Kim2, Jong Kuk Kim3,4, Nam Jun Kim4, Young Hee Kim4, Kwang-Dong Choi1orcid
Research in Vestibular Science 2020;19(4):141-143.
DOI: https://doi.org/10.21790/rvs.2020.19.4.141
Published online: December 15, 2020

1 Department of Neurology and Biomedical Research Institute, Pusan National University Hospital, Busan, Korea

2 Department of Neurology, Bongseng Memorial Hospital, Busan, Korea

3 Department of Neurology, Dong-A University Medical Center, Busan, Korea

4 Peripheral Neuropathy Research Center, Dong-A University College of Medicine, Busan, Korea

*Corresponding Author: Kwang-Dong Choi Department of Neurology, Pusan National University Hospital, 179 Gudeok-ro, Seo-gu, Busan 49241, Korea Tel: +82-51-240-7085 Fax: +82-51-240-7085 E-mail: kdchoi@pusan.ac.kr
• Received: October 26, 2020   • Revised: November 25, 2020   • Accepted: November 25, 2020

Copyright © 2020 by The Korean Balance Society. All rights reserved.

This is an open access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

  • 3,989 Views
  • 73 Download
  • Anti-GQ1b antibody syndrome, including Miller Fisher syndrome, Guillain-Barré syndrome with ophthalmoplegia, Bickerstaff's brainstem encephalitis, and acute ophthalmoplegia without ataxia, has overlapped clinical symptoms and mostly associated with anti-GQ1b immunoglobulin (Ig) G antibody. We report two cases of anti-GQ1b antibody syndrome mainly presenting with a severe headache. The 60-year-old man was admitted for severe headache and gait disturbance. Neurological examination revealed limb and truncal ataxia, areflexia, nystagmus, and ophthalmoplegia. Serum IgG anti-GQ1b antibody was positive. He recovered after intravenous (IV) immunoglobulin and steroid. The 23-year-old man suffered from severe headache (visual analogue scale=10) within the periorbital area. Ophthalmoplegia with gaze-evoked nystagmus were revealed. Serum IgG anti-GQ1b and anti-GT1a antibodies were positive. Headache was improved by IV immunoglobulin and steroid. The pathophysiology of headache in anti-GQ1b antibody syndrome is largely unknown. The affected nerve or structures in the brainstem including the trigeminovascular system may induce intractable severe headache.
Immunoglobulin (Ig) G anti-GQ1b antibody has been found in Guillain-Barré syndrome (GBS) with ophthalmoplegia, Miller Fisher syndrome (MFS), Bickerstaff brainstem encephalitis (BBE), and acute ophthalmoplegia without ataxia [1]. These diseases have overlapped clinical symptoms, so they were recently classified as ‘anti-GQ1b antibody syndrome’ [1]. This syndrome represents the variable neurological spectrum including the triad features of MFS, which are ophthalmoplegia, ataxia, and areflexia, as well as motor and sensory symptoms, consciousness disturbance, facial and bulbar palsy by their subtypes [2]. However, pain or headache associated with this syndrome is very rare. Herein, we report that two patients with severe headache confirmed with anti-GQ1b antibody syndrome.
1. Case 1
The 60-year-old man on regular hypertensive medication was admitted with progressive limb ataxia, binocular diplopia, and headache for 3 days. He complained of severe headache located around both periorbital and frontal area and exacerbated by routine physical activities and Valsalva maneuver. He denied previous headache. He could not move on, sit up, and even open his eyes because of severe pain (visual analogue scale [VAS] score, 10). The acetaminophen or nonsteroidal anti- inflammatory drugs (NSAIDs) were not effective. Initial neurological examination revealed limb and truncal ataxia, areflexia. He could not gait without assistant. Visual acuity was normal without any optic disc swelling. Although there was not spontaneous nystagmus with or without fixation, horizontal and vertical gaze-evoked nystagmus was shown with bilateral abduction palsy and adductive saccadic slowing. Cerebrospinal fluid study showed mild lymphocytosis (7/μ L) and elevated protein (78.4 mg/dL), and the opening pressure was 15 cmH2 O. Brain and orbital magnetic resonance imaging (MRI) were normal. Since there was no evidence of other infection causes, intravenous (IV) IgG (400 mg/kg/day) and dexamethasone were prescribed. After 2 days, severe headache and gaze-evoked nystagmus were subsided. He was discharged with only mild limb ataxia on the 10th hospital day. IgM and IgG anti-ganglioside antibody test using enzyme-linked immunosorbent assay (ELISA) with acute stage serum against each single ganglioside GM1, GM2, GD1a, GD1b, GD3, GT1a, GT1b, and GQ1b as described elsewhere showed positive (1+) to IgG anti-GQ1b antibody (semi-quantitative titer using subtracted optical density [OD] de-cided as follows; OD 0.1–0.29 as 1+, OD 0.3–0.49 as 2+, OD 0.5–0.99 as 3+, and OD more than 1.0 as 4+) [3]. After 2 months, the antibody was converted into negative, and he got well without any neurologic problem.
2. Case 2
The previous healthy 23-year-old man admitted binocular horizontal diplopia for 2 days. He did not have any headache history including migraine. In initial neurological examination, abduction limitation in both eyes was shown without other neurologic deficits. There were no abnormalities in serum laboratory studies, brain and orbital MRI. CSF analysis was also normal with 9 cmH2 O of the opening pressure. On the first day of hospitalization, he complained of vertigo and severe headache, which was located on the periorbital area and aggravated by routine physical activities and Valsalva maneuver. The headache was continuous during the whole day and not improved by acetaminophen or NSAIDs. He could not move his eyes, walk, or eat because of severe pain (VAS score, 10). Fundus examination and light reflex were normal, but horizontal and vertical gazeevoked-nystagmus was newly revealed. Smooth pursuit and saccades were normal. IV IgG and steroid (prednisolone 1 g/day) were started. One day after these medications, severe headache was improved. On the 7th day of hospitalization, he was discharged with only mild gaze-evoked nystagmus. ELISA with acute stage serum before treatment revealed positive IgG anti-GQ1b and anti-GT1a antibodies (each 1+) [3]. After 2 months, he recovered fully without nystagmus, and follow-up serum antibodies were all negative.
Our two patients who were confirmed as anti-GQ1b antibody syndrome by clinical manifestation and ELISA, mainly suffered from a severe headache which was not controlled by acetaminophen or NSAIDs. Severe headache or pain is a very rare complication in MFS or GBS.
In a case series of 27 patients clinically diagnosed with MFS referred to a laboratory center, six patients (22%) showed painful experience in the acute phase, and three of them had headache [4]. The locations of pain were around orbit, and its nature was diverse. Interestingly, oral NSAIDs were not effective for their headache as in our cases. In other recent study, six of the 38 patients (16%) with MFS experienced headache during the acute phase. Three of them complained of pain with over moderate (over 5 score by Wong-Baker FACES Pain Rating Scale), and NSAIDs was not effective in all patients [5]. The pathophysiology of pain or headache in anti-GQ1b anti-body syndrome is largely unknown. In a previous study about pain in GBS, clinically diverse nature of pain including radicular, painful paresthesia, muscle pain, and/or arthralgia occurs on back, extremities, neck, and/or trunk [6]. Affected nerve roots can explain the occurrence of radicular nociceptive nerve pain affecting the low back or back with radiation to extremities or trunk, and inflammatory factors via the nervi nervorum may also play a role in the pathophysiology of pain [6]. Likewise, considering the high prevalence of pain in the extremities, other neuropathic factors like small fiber neuropathy and muscle weakness may contribute to the pain in GBS [6,7].
Since anti-GQ1b antibody syndrome have common pathophysiology with GBS, which is the autoimmune response gene-rating antibodies that cross-react with ganglioside at nerve [8] pain or headache in anti-GQ1b antibody syndrome may be originated from the affected nerve and around structures. The GQ1b is broadly expressed in some cranial nerves including the trigeminal nerve [9]. Also, the GD3 and GD1b are major gan-gliosides of all cranial nerves along with the ventral and dorsal roots of the spinal cord [9]. Thus, demyelination of the cervical and cranial sensory nerves by anti-ganglioside antibodies may serve to activation of the trigeminovascular pain pathway within migraine pathophysiology, causing severe headache [10].
Otherwise, the direct involvements to the central trigemino-vascular system by ganglioside antibodies may contribute to severe headache. Ganglioside GQ1b may be expressed in reticular formation in the brainstem, so various neurological symptoms like impaired consciousness or hyperreflexia can arise in BBE [2]. In rats, locus coeruleus and near structures in pons have GM1, GD1a, GD1b, and GT1b with diverse distribution [11]. Because these structures are the passage of trigemino-vascular system, severe headache may be associated with direct inflammation on the central structures.

No potential conflict of interest relevant to this article was reported.

This work was supported by clinical research grant from Pusan National University Hospital in 2020 and the National Research Foundation of Korea (NRF) grant funded by the Korea government (MEST) (2016R1A5A2007009).
  • 1. Odaka M, Yuki N, Hirata K. Anti-GQlb IgG antibody syndrome: clinical and immunological range. J Neurol Neurosurg Psychiatry 2001;70:50–5.PubMedPMC
  • 2. Shahrizaila N, Yuki N. Bickerstaff brainstem encephalitis and Fisher syndrome: anti-GQ1b antibody syndrome. J Neurol Neurosurg Psychiatry 2013;84:576–83.ArticlePubMed
  • 3. Kim JK, Bae JS, Kim DS, Kusunoki S, Kim JE, Kim JS, et al. Prevalence of anti-ganglioside antibodies and their clinical correlates with guillain-barré syndrome in Korea: a nationwide multicenter study. J Clin Neurol 2014;10:94–100.ArticlePubMedPMC
  • 4. Koga M, Yuki N, Hirata K. Pain in Miller Fisher syndrome. J Neurol 2000;247:720–1.ArticlePubMed
  • 5. Jung JH, Oh EH, Shin JH, Kim DS, Choi SY, Choi KD, et al. Atypical clinical manifestations of Miller Fisher syndrome. Neurol Sci 2019;40:67–73.ArticlePubMed
  • 6. Ruts L, Drenthen J, Jongen JL, Hop WC, Visser GH, Jacobs BC, et al. Pain in Guillain-Barre syndrome: a long-term follow-up study. Neurology 2010;75:1439–47.ArticlePubMed
  • 7. Pan CL, Tseng TJ, Lin YH, Chiang MC, Lin WM, Hsieh ST. Cutaneous innervation in Guillain-Barré syndrome: pathology and clinical correlations. Brain 2003;126:386–97.PubMed
  • 8. van den Berg B, Walgaard C, Drenthen J, Fokke C, Jacobs BC, van Doorn PA. Guillain-Barré syndrome: pathogenesis, diagnosis, treatment and prognosis. Nat Rev Neurol 2014;10:469–82.ArticlePubMedPDF
  • 9. Chiba A, Kusunoki S, Obata H, Machinami R, Kanazawa I. Ganglioside composition of the human cranial nerves, with special reference to pathophysiology of Miller Fisher syndrome. Brain Res 1997;745:32–6.ArticlePubMed
  • 10. Friedman DI, Potts E. Headache associated with miller fisher syndrome. Headache 2007;47:1347–8.ArticlePubMed
  • 11. Byers DM, Irwin LN, Cabeza R. Ganglioside patterns mature at different rates in functionally related subregions of the rat pons. Dev Neurosci 2002;24:478–84.ArticlePubMed

Figure & Data

References

    Citations

    Citations to this article as recorded by  

      • PubReader PubReader
      • ePub LinkePub Link
      • Cite
        CITE
        export Copy
        Close
        Download Citation
        Download a citation file in RIS format that can be imported by all major citation management software, including EndNote, ProCite, RefWorks, and Reference Manager.

        Format:
        • RIS — For EndNote, ProCite, RefWorks, and most other reference management software
        • BibTeX — For JabRef, BibDesk, and other BibTeX-specific software
        Include:
        • Citation for the content below
        Anti-GQ1b Antibody Syndrome Presenting with Severe Headache
        Res Vestib Sci. 2020;19(4):141-143.   Published online December 15, 2020
        Close
      • XML DownloadXML Download
      We recommend

      Res Vestib Sci : Research in Vestibular Science