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A Case of Creutzfeldt-Jakob Disease Presenting Mainly with Abnormal Eye Movements
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Yeo Jeong Kang, Jun Hyun Kim, Tae Eun Kim, Sun Ah Park, Tae Kyeong Lee
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Res Vestib Sci. 2014;13(2):53-56.
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 Abstract
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- Creutzfeldt-Jakob disease (CJD) is a human prion disease with rapidly progressive neurodegeneration. The major clinical manifestations of CJD include mental deterioration, myoclonus, cerebellar dysfunction, and neuro-ophthalmic symptoms and signs. However, abnormal eye movements as an early sign of CJD are rare. We report a 49-year-old man with periodic alternating nystagmus in early disease course.
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Upbeat Nystagmus in Association with Wall-Eyed Bilateral Internuclear Ophthalmoplegia
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Duck Su Park, Yeo Jeong Kang, Tae Kyeong Lee, Kwang Ik Yang
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Res Vestib Sci. 2014;13(1):24-27.
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Abstract
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- A 54-year-old man presented with primary position upbeat nystagmus and wall-eyed bilateral internuclear ophthalmoplegia. He also showed bilateral limb ataxia and impaired horizontal gaze. Upbeat nystagmus obeyed Alexander’s law and attenuated by visual fixation and disappeared by convergence. Brain magnetic resonance imaging showed acute infarction in the bilateral paramedian midbrain involving the crossing of brachium conjunctivum. Multiple mechanisms including the interruption of central vestibulo-ocular projections from anterior canal may be postulated in upbeat nystagmus of this patient.
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KBS
