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Four Cases of Wernicke’s Encephalopathy with Impaired Horizontal Vestibular Ocular Reflexes
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Hyuk su Jang, Sun-Young Oh, Byoung-Soo Shin, Man-Wook Seo
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Received April 24, 2017 Accepted June 2, 2017 Published online June 2, 2017
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[Accepted]
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 Abstract
- Wernicke's encephalopathy (WE) is a neurological disorder induced by a dietary vitamin B1 (thiamine) deficiency. It is characterized by encephalopathy, gait ataxia, and some variant of oculomotor dysfunction which are the classic triad of WE. However, a complicating factor of WE identification may not be associated with the classical clinical triad in up to 90% of patients. In recent years, a loss of the horizontal vestibulo-ocular reflex (VOR) is being reported as the major underdiagnosed symptoms in WE. In this retrospective single center study, we describe four cases of WE presented mainly impaired horizontal VOR in addition to the classical clinical presentations, and imaging and neurotological laboratory findings were described.
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Cerebellar ataxia, Neuropathy, Vestibular Areflexia Syndrome (CANVAS) 환자에서 뇌 대사감소
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Byoung-Min Jeong, Byoung-Soo Shin, Man-Wook Seo, Ji-Yun Park, Hwan-Jeong Jeong, Sun-Young Oh
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Received November 4, 2017 Accepted November 29, 2017 Published online November 29, 2017
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[Accepted]
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Abstract
- Cerebellar ataxia with neuropathy and vestibular areflexia syndrome (CANVAS) is a slowing progressive ataxic disorder characterized by bilateral vestibulopathy, cerebellar ataxia and somatosensory impairment. Autonomic dysfunction is recently considered as a core feature in CANVAS in addition to these symptoms. In most cases, patients with CANVAS show cerebellar atrophy in brain imaging, but some cases show minimal or no atrophy of cerebellum. Brain 18F-FDG PET study can be a complimentary tool to diagnosis CANVAS in cases of no structural abnormality such as cerebellar atrophy. Hereby, we present a case of CANVAS with minimal atrophy of cerebellum but showing a prominent hypometabolism in cerebellum, thalamus and posterior cingulate cortex in 18F-FDG PET.
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KBS
