Nystagmus is defined as spontaneous, involuntary, to-and-fro movement of eyes caused by retinal slip. Observation of nystagmus is the core examination in patients with vertigo or balance disorders. The interpretation of nystagmus requires familiarity with the types of nystagmus and differential diagnosis for common diseases and location of lesion. Here we review the features of nystagmus arising from different conditions and related disease.