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HOME > Res Vestib Sci > Volume 8(2); 2009 > Article
Case Report Downbeat, Gaze-evoked and Perverted Head-shaking Nystagmus Associated with Dapsone Toxicity
Tae Woo Kim, Sun Young Oh, Ha Cheol Choi, Byoung Soo Shin, Man Wook Seo, Young Hyun Kim

DOI: https://doi.org/
Department of Neurology, Chonbuk National University College of Medicine, Jeonju, Korea. ohsun@chonbuk.ac.kr
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Dapsone is an agent commonly used to treat leprosy and its most common adverse effect is a hemolytic anemia. We present a patient who showed transient downbeat, bilateral horizontal gaze-evoked nystagmus (GEN), and perverted head-shaking nystagmus after taking a large dose of dapsone. These oculomotor abnormalities are assumed to be a reversible vestibulocerebellar dysfunction caused by over-dose of dapsone.


Res Vestib Sci : Research in Vestibular Science