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- Case Report A Case of Apogeotropic Positional Nystagmus Associated With Anti-GD1b IgG Antibody
- Seong Hae Jeong, Gun Sei Oh, Dong Ick Shin, Ji Soo Kim
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DOI: https://doi.org/
1Department of Neurology, Eulji University School of Medicine, Eulji University Hospital, Daejeon, Korea. mseaj@eulji.ac.kr 
2Department of Neurology, Chungbuk National University, College of Medicine, Chungbuk National University Hospital, Korea.
3Department of Neurology, Seoul National University, College of Medicine, Seoul National University Bundang Hospital, Korea.
2Department of Neurology, Chungbuk National University, College of Medicine, Chungbuk National University Hospital, Korea.
3Department of Neurology, Seoul National University, College of Medicine, Seoul National University Bundang Hospital, Korea.
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Abstract
The binding of anti-GD1b IgG antibody to the cerebellar granular area or spinocerebellar Ia fibers in the peripheral nerves may cause the prominent cerebellar ataxia, mild quadriparesis and sensory dominant neuropathy. A 31-year woman presented with severe cerebellar ataxia and prominent apogeotropic positional nystagmus/vertigo. Increased anti-GD1b antibody IgG in her serum was noted. 18F-flurodeoxyglucose positron emission tomography (FDG-PET) showed decreased uptake in cerebellum. It is the first case of central positional nystagmus with anti-GD1b IgG antibody.
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