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- Original Article Expression of Glutamate Receptors in the Medial Vestibular Nuclei following Acute Hypotension
- Jae Hee Lee, Myoung Ae Choi, Dong Ok Choi, Bo Kyoung Kim, Seok Min Hong, Byung Rim Park
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DOI: https://doi.org/
1Department of Physiology, Wonkwang University School of Medicine and Vestibulocochlear Research Center at Wonkwang University, Iksan, Korea. byungp@wku.ac.kr 
2Department of Otorhinolaryngology and Head & Neck Surgery, College of Medicine, Kyunghee University, Seoul, Korea.
2Department of Otorhinolaryngology and Head & Neck Surgery, College of Medicine, Kyunghee University, Seoul, Korea.
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Abstract
Acute hypotension induced excitation of electrical activities and expression of c-Fos protein and pERK in the vestibular nuclei. In this study, to investigate the excitatory signaling pathway in the vestibular nuclei following acute hypotension, expression of NR2A and NR2B subunits of glutamate NMDA receptor and GluR1 subunit of glutamate AMPA receptor was determined by RT-PCR and Western blotting in the medial vestibular nucleus 30 min after acute hypotension in rats. Acute hypotension increased expression of NR2A, NR2B, and pGluR1 in the medial vestibular nuclei. These results suggest that both of NMDA and AMPA glutamate receptors take part in transmission of excitatory afferent signals following acute hypotension.
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