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Research in Vestibular Science > Volume 15(1); 2016 > Article
Research in Vestibular Science 2016;15(1): 11-16.
소동물 전정안구반사 측정용 마커 어레이의 최적화
, , , , , , , 김미주1, 이지연1, 홍의재2, 이은지2, 민유진1, 이동주2, 김남범3, 한규철2
1가톨릭관동대학교 국제성모병원 이비인후-두경부교실, 가천대학교 2이비인후과학교실, 3뇌과학연구원
Vestibulo-Ocular Reflex Recordings of Small Rodents using a Novel Marker Array
Mi Joo Kim, Jiyeon Lee, Eui Jae Hong, Eun Ji Lee, Yu Jin Min, Dong Ju Lee, Nam Beom Kim, Gyu Cheol Han
1Department of Otorhinolaryngology, Catholic Kwandong University International ST. Mary's Hospital, Incheon, Korea.
2Department of Otolaryngology-Head and Neck Surgery, Gachon University of Medicine and Science, Graduate School of Medicine, Incheon, Korea. hangckr@gmail.com
3Neuroscience Research Institute, Gachon University, Graduate School of Medicine, Incheon, Korea.
Objective:   Recording the nystagmus of small experimental rodents is an integral technique in vestibular research. Theoretically, the size and the shape of markers strongly affect the analysis of 3 dimensional nystagmus.
Method:   The nystagmus of 6 healthy ICR mice were recorded and their gain values were compared using 200 μm, 300 μm, 400 μm, and 600 μm isosceles triangle markers at the peak velocity of 60o/sec and 100o/sec with the rotational stimulations of 0.1 Hz, 0.2 Hz, and 0.5 Hz.
Results:   The gain values of 3 different sizes of the markers showed no significant differences in horizontal- vertical-torsional component. However, it was unable to record the nystagmus with 200 μm markers since the markers were too small to be placed and stayed on the center of the pupils.
Conclusion:   Technicians can decide the size of the markers from 200 to 600 ?m to record the nystagmus of mice, depending on the technicians’ skills.
Keywords: Vestibulo-ocular reflex; Marker; Video-nytagmography; Mice
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