Objectives
There were few recent study concern about usefulness of CHAMP in progression of Meniere’s disease. The purpose of this study is to analyze changes in the CHAMP as advancement of Meniere's disease.
Methods
We studied 19 cases of ‘Definite’ group of Meniere’s disease. We assumed progression of Meniere’s disease would be checked by pure tone threshold by four tone average(4PTA), low tone average(LPTA). We also compared electrocochleography(ECoG), dizziness handicap inventory(DHI), tinnitus handicap inventory(THI) as parameters for progression of Meniere’s disease to CHAMP latency delay and amplitude ratio. Chi-square test, Linear by linear association test were used as a statistical method.
Results
In the group of patients had abnormal amplitude ratio, ECoG value were not improved, but there was not statistically significant.(odds ratio(OR)=5.727,P>0.05) Better DHI and THI score were not necessarily construed as the improvement value in the CHAMP.(P>0.05) In amplitude ratio abnormal group, 4PTA was aggravated, but not statistically significant.(OR=1.5, P>0.05). In the group of patient had abnormality in both latency delay and amplitude ratio, LPTA was relatively aggravated.(OR in latency delay:2, OR in amplitude ratio:10), however, reveals no statistically significance between them.(P>0.05) Change of ECoG, hearing threshold including 4PTA and LPTA with progression of Meniere’s disease were not correlated significantly with latency delay or amplitude ratio of CHAMP.
Conclusions
We conclude that CHAMP does not reflect clinical features with progression of Meniere’s disease.